RED FLAGS
Red flags are specific history, symptoms, or signs that may suggest underlying causative disorders and heighten
awareness of secondary headaches. A combination of compatible red flags may increase their significance. However, the
absence of red flags is useful for excluding secondary headaches, whereas their presence is less useful for confirming
them and requires further evaluation.
The red flags used in the VTD HEADACHE ASSESSMENT are listed below, along with their
suggested possible disorders
(SNNOOP10) [ref.1,2].
Systemic symptoms including fever
• Fever : infections
Neoplasm in history
• Neoplasm (health problem) :
neoplasms, metastasis
Neurologic deficit or dysfunction including decreased consciousness
• Neurologic deficit • Seizure : vascular
or
nonvascular disorders, infections
Onset of headache is sudden or abrupt
• Sudden and severe : subarachnoid
hemorrhage,
vascular disorders
Older age (after 50 years)
• Age onset (years) > 50
: neoplasms, vascular or nonvascular disorders, giant cell
arteritis
Pattern Change or recent onset of new headache
• First attack • Newly developed (< 3 months)
: neoplasms, vascular or nonvascular disorders
Positional headache
• Changing to upright posture
: intracranial hypotension
Precipitated by sneezing, coughing, or exercise
• Valsalva
: posterior fossa lesions, Chiari malformation
• Exercise or sexual activity (on first occurrence)
: subarachnoid hemorrhage, vascular disorders
• Chewing
: giant cell arteritis, TMJ disorders
Papilledema
• papilledema
: neoplasms, nonvascular disorders, intracranial hypertension
Progressive headache and atypical presentations
• Progressive worsening
: neoplasms, nonvascular disorders
Pregnancy or puerperium
• Pregnancy or puerperium
: hypertension, preeclampsia, eclampsia, cerebral sinus thrombosis,
hypothyroidism, postdural puncture
Painful eye with autonomic features
• Painful eye with autonomic symptoms
: pathology in posterior fossa, pituitary region, or cavernous sinus; Tolosa-Hunt syndrome;
ophthalmic causes
Posttraumatic onset of headache
• Head injury (< 3 months)
: posttraumatic headache, subdural hematoma
Pathology of the immune system such as HIV
• Immunodeficiency • steroids
: opportunistic infections
Painkiller overuse or new drug at onset of headache
• Pain relievers > 10-15 days/month > 3 months
: medication-overuse headache
• Using the drugs underlined on page 2 of the form
: drug-induced headache
• Antiplatelets, anticoagulants
: intracranial hemorrhage
PRACTICAL TIPS
1. The device used for assessment can be either the patient’s or the physician’s mobile phone or
tablet, depending on the situation. Assessment reports are stored on the device used and can be
accessed through the History menu.
2. The submitted questionnaire can be reviewed and revised using the Back button, the Search menu, or the History menu, and
the assessment report will be updated accordingly.
3. For easier use in some situations, the patient may complete part of the questionnaire on general history and red flags
(black and red question numbers) and submit it. Later, the patient and physician can jointly complete the remaining
questions on the diagnostic criteria (green question numbers), which require greater clinical accuracy.
4. When the symbol suggests chronic migraine, the questionnaire evaluates the patient’s overall
headache pattern rather than the ≥8 days/month with migrainous features specified in ICHD-3
diagnostic criteria.
5. For use as a headache diary to count the number of headache days with migrainous features in
patients with headache on ≥15 days/month for >3 months, the patient completes the
green-numbered questions for each headache day. If the suggestions include chronic migraine, that
headache day is counted as one with migrainous features for the purpose of assessing the ICHD-3
chronic migraine criterion.
If headache on ≥15 days/month has been present for only 1–3 months, this method can also be used
to count headache days with migrainous features. However, for this purpose, the patient must
select “more than 3 months” in question 14.2.
6. When suggesting TACs, only Pr is marked in both columns. The questionnaire primarily evaluates
moderate-to-severe unilateral headache with ipsilateral cranial autonomic symptoms. It suggests
TACs as a group rather than the ICHD-3 probable diagnoses.